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Welcome to the BREED publications collection
The Biology of Reproduction, Environment, Epigenetics and Development (BREED) joint research unit studies the effects of environment, in the broadest sense, on reproduction, development during embryonic and foetal life and the health of offspring. It gathers researchers, hospital clinicians and veterinarians for both agronomic and biomedical research.
The scientific context is based on the need to understand and control the mechanisms of epigenetic programming during prenatal life leading to the birth of a healthy, fertile and robust individual, capable of adapting to changes in its environment.
The aims of our research are to improve fertility and the efficiency of reproductive biotechnologies in humans and animals, to study the physiological and molecular mechanisms that determine the phenotypes of the offspring (health, growth, fertility, etc.) and to identify predictive and non-invasive biomarkers for these phenotypes, some of which could complement genetic selection strategies in animals. The unit relies on research involving several animal models (rabbits, ruminants, rodents, horses) and multiple and complementary imaging approaches, from the microscopic scale to the whole live animal. In vitro models are also developed as alternatives to animal experimentation (primary cell cultures, organoids, embryoids). This expertise and tools are complemented by clinical studies conducted by hospital and veterinary practitioners.
Last additions
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Amarnath Rambhatla, Rupin Shah, Imad Ziouziou, Priyank Kothari, Gianmaria Salvio, et al.. Global Practice Patterns and Variations in the Medical and Surgical Management of Non-Obstructive Azoospermia: Results of a World-Wide Survey, Guidelines and Expert Recommendations. The World Journal of Men's Health, 2024, 42, ⟨10.5534/wjmh.230339⟩. ⟨hal-04569819⟩
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Nicolas Jovanovic, Vicente Mustieles, Marc Althuser, Sarah Lyon-Caen, Nadia Alfaidy, et al.. Associations between synthetic phenols, phthalates, and placental growth/function: a longitudinal cohort with exposure assessment in early pregnancy. Human Reproduction Open, 2024, 2024, ⟨10.1093/hropen/hoae018⟩. ⟨hal-04569675⟩
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Géraldine Porcu-Buisson, Chloé Maignien, Nelly Swierkowski-Blanchard, Catherine Rongières, Noémie Ranisavljevic, et al.. Prospective multicenter observational real-world study to assess the use, efficacy and safety profile of follitropin delta during IVF/ICSI procedures (DELTA Study). European Journal of Obstetrics & Gynecology and Reproductive Biology, 2024, 293, pp.21-26. ⟨10.1016/j.ejogrb.2023.12.011⟩. ⟨inserm-04391221⟩
References
2 231
Open Access
33 %
Keywords
Spermatozoa
Développement embryonnaire
Goat
Animal model
Développement
Implantation
Placenta
Cheval
Obesity
Inflammation
Endomètre
Sex determination
Mouse
Mice
BIOLOGIE DU DEVELOPPEMENT
Conceptus
Foxl2
Blastocyst
Environment
These
NUCLEAR TRANSFER
Humans
Obésité
Meiosis
Animal modèle
Trophoblast
Souris
IMMUNOLOGIE
Growth
GENOMIQUE
Gestation
IMAGERIE
Bovine
Pregnancy
Poulain
GENETIQUE
Embryo
PLACENTA
Horse
Méthylation
Fetal programming
Ruminant
Somatic cell nuclear transfer
Mare
Nuclear transfer
Epigenetics
Métabolisme
Ovary
DOHaD
Endometrium
IMAGE
Pluripotency
Phénotype
Female
Development
Infertility
Epigenetic
Transcriptome
Oocyte
Bovin
Gene expression
Diesel
Cattle
Progesterone
Uterus
Lapin
Mammary gland
Fertility
Reproduction
Spermatogenesis
Adult
Rabbit
Male infertility
Fertilité
Programmation foetale
Methylation
EMBRYO
Male
Animal models
DNA methylation
Jument
Embryon
Dairy cow
Dna methylation
Épigénétique
Alimentation
Dohad
Ovaire
Epigénétique
Oxidative stress
Foetus
Embryo transfer
Chorion
Equine
Programming
BIOTECHNOLOGIE
Sperm
Sexual dimorphism
Sheep
Nutrition